Talk:Diphenhydramine

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Addiction

I think the risk is low i dont think its moderate since I never seen someone addicted to this and i work at addiction clinic for over 20 years and seen addiction to many drugs but not diphenhydramine its also otc and not controlled substance 64.223.128.102 (talk) 15:25, 28 March 2023 (UTC)[reply]

Can this drug be taken for a person with aphib? 24.43.226.52 (talk) 16:59, 25 June 2023 (UTC)[reply]

Using PMID: 23357028 (Citatin [61]) as a source for potentially wrong (in the case of Diphenhydramine) many listed pharmacological binding affinities in this wiki

I think this is problematic issue as this citation for this paper, (PMID: 23357028) upon inspection, it is simply reviewing an extremely wide variety of antihistamanergic drugs, in the paper no actual claims are made that diphenhydramine has any direct activity at dopamine 2 receptors or 5-HT2A receptors, i think any entry on this wiki page using this paper as a citation should be reviewed. Databoose43 (talk) 11:01, 4 February 2024 (UTC)[reply]

Anxiety

I used Diphenhydramine for anxiety for a long time, and it works, although its not approved to treat Anxiety. Of course, this is an off label use, but it works. My friends also tell me how much it helped them, so I added a sub section under Medical uses for this. There are many other anti histamines, and they are meant to treat anxiety. For example Hydroxyzine. But Hydroxyzine requires a prescription, while Benadryl can be purchased without a prescription. A prescription can be difficult to get sometimes, and when you need something quick and easy to get to help you relax, Benadryl is a good temporary choice. I was hoping if somebody can please help improve the article by adding more details about Diphenhydramine's ability to help with Anxiety. It also has antidepressant properties, which is mentioned somewhere in the article, but there's not enough details it seems.

For now, I only added the anxiety sub section. Noam Atadgy (talk) 02:41, 8 November 2024 (UTC)[reply]